Semiconductor single particle counting pixel detectors offer many advantages for radiation imaging: high detection efficiency, energy discrimination, noiseless digital integration (counting), high frame rate and virtually unlimited dynamic range. All these properties allow to achieve high quality images. Examples of transmission images and 3D tomographic reconstruction using X-rays and slow neutrons are presented demonstrating effects that can affect the quality of images. A number of obstacles can limit detector performance if not handled. The pixel detector is in fact an array of individual detectors (pixels), each of them has its own efficiency, energy calibration and also noise. The common effort is to make all these parameters uniform for all pixels. However, an ideal uniformity can be never reached. Moreover, it is often seen that the signal in one pixel affects neighboring pixels due to various reasons (charge sharing, crosstalk ...). All such effects have to be taken into account during data processing to avoid false data interpretation. The main intention of this contribution is to summarize techniques of data processing and image correction to eliminate residual drawbacks of pixel detectors. It is shown how to extend these methods to handle further physical effects such as hardening of the beam and edge enhancement by deflection. Besides, more advanced methods of data processing such as tomographic 3D reconstruction are discussed. All methods are demonstrated on real experiments from biology and material science performed mostly with the Medipix2 pixel device. A brief view to the future of pixel detectors and their applications including also spectroscopy and particle tracking is given too.